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Fig. 2 | Molecular Medicine

Fig. 2

From: Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients

Fig. 2

TRPM3 activity after PregS stimulation. Data were obtained under whole-cell patch clamp conditions. a A representative time-series of current amplitude at + 100 mV and − 100 mV showing the effect of 100 μΜ PregS on ionic currents in isolated NK cells from HC. b IV before and after PregS stimulation in a cell corresponding with (a.). c A representative time-series of current amplitude at + 100 mV and − 100 mV showing the effect of 100 μΜ PregS on ionic currents in isolated NK cells from CFS/ME patients. d. IV before and after PregS stimulation in a cell as shown in (c.). e Bar graphs representing TRPM3 current amplitude at + 100 mV after stimulation with 100 μΜ PregS in CFS/ME patients (N = 6; n = 33) compared with HC (N = 6; n = 29). Data are represented as mean ± SEM. Abbreviations: CFS/ME, chronic fatigue syndrome/myalgic encephalomyelitis; HC, healthy control; NK, natural killer

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