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Fig. 1 | Molecular Medicine

Fig. 1

From: Propofol inhibited autophagy through Ca2+/CaMKKβ/AMPK/mTOR pathway in OGD/R-induced neuron injury

Fig. 1

Establishment of neuronal ischemia-reperfusion injury model. Primary cerebral cortical neurons were prepared from Sprague-Dawley rats, and an in vitro cellular model of cerebral ischemia and reperfusion injury was induced by oxygen-glucose deprivation/reoxygenation (OGD/R). a Morphological changes of the rat primary cortical neurons cultured for 10 days were observed under a microscope (scale bar: 50 μm). b Neuron-specific enolase (NSE) immunohistochemistry staining in cortical neurons (scale bar: 50 μm). c Cell injury of cortical neurons exposed to OGD/R was evaluated by lactate dehydrogenase (LDH) release rate, and d cell viability was assessed by the CCK-8 assay. Values are represented as the mean ± SD from three independent experiments. **p < 0.01 vs. Control group

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