Fig. 5

Discriminatory power of miR-143 and miR-150 in whole blood. a Predictive modeling and Area-under-the-ROC-curve generation. Candidate miRNAs were selected for predictive modeling: miR-143, miR-150 and miR-223 in whole blood samples of septic patients compared to healthy controls, n = 10/20 (NC/Sepsis). The shadowed areas denote the confidence interval for the area under the curve. b MiRNA quantification cycles of human CD4⁺ T-cells and whole blood cells. Samples of septic patients and healthy controls were measured, n = 10/20 (NC/Sepsis),performed in duplicates. Equal amounts of RNA were used to determine quantification cycles of miR-143, miR-150, miR-223 and miR-342 by TaqMan miRNA assay. Data are shown as median, 25th and 75th percentile and outliers