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Fig. 6 | Molecular Medicine

Fig. 6

From: Suppressed microRNA-96 inhibits iNOS expression and dopaminergic neuron apoptosis through inactivating the MAPK signaling pathway by targeting CACNG5 in mice with Parkinson’s disease

Fig. 6

Lower Bax and higher Bcl-2 were found after transfection of miR-96 inhibitor. a TUNEL staining of dopaminergic neuronal tissues among seven groups (× 100); b positive cells among seven groups under a microscope; c mRNA expression of Bax and Bcl-2 among seven groups evaluated by RT-qPCR; d protein expression of Bax and Bcl-2 among seven groups evaluated by Western blot; e protein bands of Bax and Bcl-2 among seven groups; Bar = 50 μm. The test was repeated three times independently, and the one-way ANOVA analysis was used for comparison among multiple groups (n = 10 in each group). *, P < 0.05 compared with the normal group, #, P < 0.05 compared with the PD and NC groups; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling; RT-qPCR, reverse transcription quantitative polymerase chain reaction; Bcl-2, B-cell lymphoma-2; Bax, Bcl-2 associated protein X; miR-96, microRNA-96; CACNG5, calcium voltage-gated channel auxiliary subunit gamma 5; PD, Parkinson’ disease; NC, negative control

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