Murine exposure to gold nanoparticles during early pregnancy promotes abortion by inhibiting ectodermal differentiation

Table 4 Estrogen serum concentration and level of aborted or non-aborted pregnant mice

Grouping	Mouse number	E2 content (pmol/L)	E2 level definition	P content (nmol/L)	P level definition	Abortion status
NP	NP-1	123.9	H	190.1	H	N
	NP-2	71.6	L	> 190.8	H	N
	NP-3	113.7	H	> 190.8	H	N
	NP-4	111.9	H	> 190.8	H	N
	NP-5	101.5	H	> 190.8	H	N
	NP-6	96.4	L	7.8	L	Y
	NP-7	54.3	L	41.8	L	Y
	NP-8	119.8	H	> 190.6	H	N
	NP-9	116.3	H	> 190.1	H	N
	NP-10	109.5	H	> 190.8	H	N
A30E	A30E-1	67.1	L	3.9	L	Y
	A30E-2	79.4	L	161.8	H	Y
	A30E-3	56.6	L	29.6	L	Y
	A30E-4	123.8	H	> 190.8	H	N
	A30E-5	62.5	L	19	L	Y
	A30E-6	46.8	L	88	L	Y
	A30E-7	124.5	H	> 190.8	H	N
	A30E-8	47.3	L	26.2	L	Y
	A30E-9	111.9	H	> 190.8	H	N
	A30E-10	123.9	H	> 190.8	H	N
A30L	A30L-1	56.1	L	3.9	L	Y
	A30L-2	115.7	H	> 190.8	H	N
	A30L-3	114.7	H	> 190.8	H	N
	A30L-4	62.9	L	15.2	L	Y
	A30L-5	133.1	H	190.1	H	N
	A30L-6	108.4	H	> 190.8	H	N
	A30L-7	121.2	H	190.1	H	N
	A30L-8	126.1	H	> 190.8	H	N
	A30L-9	106.7	H	> 190.8	H	N
	A30L-10	118.3	H	> 190.8	H	N

Pregnant mice in different groups were sacrificed in E16.5 and checked for abortion. In “Abortion status” column, Y means abortion, and N means non-abortion. The serum of each mouse was collected at the same time for the estrogen content assays of estradiol (E2) and progesterone (P). The level of estrogen was defined by comparing with the setting value: E2 concentration above 100 pmol/L is identified as high level (H), lower than 100 pmol/L is identified as low level (L). P concentration above 100 nmol/L is identified as high level (H), lower than 100 nmol/L is identified as low level (L). In the Table, the estrogen concentrations, estrogen level definition and abortion statuses of each mouse were listed correspondingly to show the relationship among abortion, estrogen level change and A30 exposure

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