Fig. 7

Fibrosis and condensed collagen deposition in rat urinary bladder following cyclophosphamide (CYP) stimulation with and without GPR120 agonist / extracorporeal shock wave treatment (ESWT). Masson’s trichrome and Sirius red-stained bladder sections showing normal urothelium in sham controls with (a, g) and without (b, h) ESWT. Fibrotic bladder noted in rats following CYP treatment (c, i). Significant inhibition of bladder fibrosis after ESWT (d, j) and GPR120 agonist (i.e., GW9508) (e, k) treatment. f, l Summary of differences in bladder fibrotic area in the five groups of animals (n = 6 per group). Values expressed as the mean ± SEM. *p < 0.05, **p < 0.01 vs. CYP; ^††p < 0.01 vs. controls; ns, non-significance. Significance of differences determined by one-way ANOVA followed by Bonferroni’s post-hoc comparisons tests. Scale bars in right lower corner represent 50 μm. SC = sham control; CYP = cyclophosphamide; ESWT = extracorporeal shock wave treatment; GW9508 = GPR120 agonist