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Fig. 1 | Molecular Medicine

Fig. 1

From: Angiopoietin 1 influences ischemic reperfusion renal injury via modulating endothelium survival and regeneration

Fig. 1

a Design of inducible whole body Angpt1 knockout mice. Angpt1 exon 3 floxed Angpt1flox/flox mice were mated with UBC/CreErt2(Tg) mice to generate the UBC-CreErt2(Tg)/Angpt1flox/flox mice. After the induction with tamoxifen, exon 3 of Angpt1 was excised. The truncated Angpt1 mRNA was expressed and degraded or abnormal Angpt1 protein was translated. b Design of renal tubule specific inducible Angpt1 over-expression mice. Pax8-rtTA(Tg) mice were mated with pTre-hAngpt1(Tg) mice to generate the Pax8-rtTA(Tg)/pTre-hAngpt1(Tg) mice. After the induction with doxycycline, the renal tubule began to generate human Angpt1 mRNA

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Molecular Medicine

ISSN: 1528-3658