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Fig. 8 | Molecular Medicine

Fig. 8

From: Astragalus polysaccharides suppresses high glucose-induced metabolic memory in retinal pigment epithelial cells through inhibiting mitochondrial dysfunction-induced apoptosis by regulating miR-195

Fig. 8

Overexpression of miR-195 increased the oxidative stress and mitochondrial damage in ARPE-19 cells. a MiR-195 mimics significantly increased the miR-195 level and decreased the Bcl-2 level which were modulated by APS treatment in HG and HG + NG treated ARPE-19 cells. b MiR-195 mimics increased the MDA and decreased SOD levels which were regulated by APS in HG and HG + NG treated ARPE-19 cells. c Immunostaining showed miR-195 mimics significantly increased the ratio of monomeric (Green) to aggregate (Red) JC-1 which was decreased by APS in HG or HG + NG treated ARPE-19 cells. d The statistical results of mitochondrial membrane potential in C. e Western blotting showed miR-195 mimics significantly decreased the ratio of mitochondrial to cytosol cyt-c which was increased by APS in HG and HG + NG treated ARPE-19 cells. f The statistical results of ratio of mitochondrial to cytosol cyt-c. Error bars represented mean ± SD. *** p < 0.001, ** p < 0.01, * p < 0.05

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Molecular Medicine

ISSN: 1528-3658