Fig. 1

Regional metabolic activity was decreased in the WT mice after binge alcohol and deficiency in CIRP attenuated these decreases in metabolic activities. a ¹⁸FDG-PET images from WT mice were analyzed by SPM8 software. Regions with decreased metabolic activity were aligned onto a standard mouse MRI brain template and regions anatomically identified based on a three-dimensional mouse brain atlas (Paxinos and Franklin 2008). Using bregma as the reference point, the Y-coordinate corresponds to the anterior-posterior (AP) distance from bregma in the coronal plane, the X-coordinate corresponds to the sagittal or mediolateral (ML) plane, and the Z-coordinate corresponds to the axial or dorsoventral (DV) views of the brain regions. b Percent changes in globally normalized metabolic values in WT and CIRP^−/− (KO) mice of specific regions identified in the WT group. Data are expressed as mean ± SE; * P < 0.05, * P < 0.001; # P = 0.069, KO vs. WT mice of respective regions