Extracellular cold inducible RNA-binding protein mediates binge alcohol-induced brain hypoactivity and impaired cognition in mice

Table 4 Regional metabolic activity in regions identified in the WT mice after binge alcohol. Percent changes in regional metabolic activity in the WT and CIRP^−/− mice treated with alcohol or normal saline (mean ± SE). * P < 0.05 and ** P < 0.01 between pre- and post-saline treatment within groups

Regions	Anatomical Regions	Alcohol			Saline
Regions	Anatomical Regions	WT (% change)	KO (% change)	P	WT (% change)	KO (% change)	P
R11	Agranular insular cortex, dorsal part	−12.7 ± 1.4	−3.5 ± 1.9	0.001	−3.6 ± 3.1	−1.3 ± 3.1	0.84
R13	Secondary visual cortex, lateral area	−10.8 ± 1.6	0.6 ± 4.4	0.029	1.0 ± 5.0	7.7 ± 7.1	0.46
R14	Glomerular layer of the olfactory bulb	−16.1 ± 2.4	−15.5 ± 2.8	0.887	10.6 ± 10.3	−12.5 ± 5.1	0.08
R15	Entorhinal/perirhinal cortex	−17.2 ± 2.4	−8.6 ± 3.5	0.069	−11.1 ± 3.9	−7.2 ± 7.1	0.64
R17	Spinal trigeminal tract	−15.8 ± 2.3	−16.5 ± 3.2	0.501	−2.9 ± 6.7	−19.0 ± 5.1	0.09
R18	Spinocerebellar tract	−31.7 ± 4.9	− 32.9 ± 6.1	0.878	0.03 ± 13.2	−7.2 ± 14.0	0.72
R19	Primary somatosensory cortex, barrel field	−11.9 ± 2.3	−3.4 ± 2.4	0.02	−10.3 ± 1.9**	−10.9 ± 3.7*	0.88

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