Table 4 Regional metabolic activity in regions identified in the WT mice after binge alcohol. Percent changes in regional metabolic activity in the WT and CIRP−/− mice treated with alcohol or normal saline (mean ± SE). * P < 0.05 and ** P < 0.01 between pre- and post-saline treatment within groups
Regions | Anatomical Regions | Alcohol | Saline | ||||
|---|---|---|---|---|---|---|---|
WT (% change) | KO (% change) | P | WT (% change) | KO (% change) | P | ||
R11 | Agranular insular cortex, dorsal part | −12.7 ± 1.4 | −3.5 ± 1.9 | 0.001 | −3.6 ± 3.1 | −1.3 ± 3.1 | 0.84 |
R13 | Secondary visual cortex, lateral area | −10.8 ± 1.6 | 0.6 ± 4.4 | 0.029 | 1.0 ± 5.0 | 7.7 ± 7.1 | 0.46 |
R14 | Glomerular layer of the olfactory bulb | −16.1 ± 2.4 | −15.5 ± 2.8 | 0.887 | 10.6 ± 10.3 | −12.5 ± 5.1 | 0.08 |
R15 | Entorhinal/perirhinal cortex | −17.2 ± 2.4 | −8.6 ± 3.5 | 0.069 | −11.1 ± 3.9 | −7.2 ± 7.1 | 0.64 |
R17 | Spinal trigeminal tract | −15.8 ± 2.3 | −16.5 ± 3.2 | 0.501 | −2.9 ± 6.7 | −19.0 ± 5.1 | 0.09 |
R18 | Spinocerebellar tract | −31.7 ± 4.9 | − 32.9 ± 6.1 | 0.878 | 0.03 ± 13.2 | −7.2 ± 14.0 | 0.72 |
R19 | Primary somatosensory cortex, barrel field | −11.9 ± 2.3 | −3.4 ± 2.4 | 0.02 | −10.3 ± 1.9** | −10.9 ± 3.7* | 0.88 |