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Table 4 Regional metabolic activity in regions identified in the WT mice after binge alcohol. Percent changes in regional metabolic activity in the WT and CIRP−/− mice treated with alcohol or normal saline (mean ± SE). * P < 0.05 and ** P < 0.01 between pre- and post-saline treatment within groups

From: Extracellular cold inducible RNA-binding protein mediates binge alcohol-induced brain hypoactivity and impaired cognition in mice

Regions Anatomical Regions Alcohol Saline
WT (% change) KO (% change) P WT (% change) KO (% change) P
R11 Agranular insular cortex, dorsal part −12.7 ± 1.4 −3.5 ± 1.9 0.001 −3.6 ± 3.1 −1.3 ± 3.1 0.84
R13 Secondary visual cortex, lateral area −10.8 ± 1.6 0.6 ± 4.4 0.029 1.0 ± 5.0 7.7 ± 7.1 0.46
R14 Glomerular layer of the olfactory bulb −16.1 ± 2.4 −15.5 ± 2.8 0.887 10.6 ± 10.3 −12.5 ± 5.1 0.08
R15 Entorhinal/perirhinal cortex −17.2 ± 2.4 −8.6 ± 3.5 0.069 −11.1 ± 3.9 −7.2 ± 7.1 0.64
R17 Spinal trigeminal tract −15.8 ± 2.3 −16.5 ± 3.2 0.501 −2.9 ± 6.7 −19.0 ± 5.1 0.09
R18 Spinocerebellar tract −31.7 ± 4.9 − 32.9 ± 6.1 0.878 0.03 ± 13.2 −7.2 ± 14.0 0.72
R19 Primary somatosensory cortex, barrel field −11.9 ± 2.3 −3.4 ± 2.4 0.02 −10.3 ± 1.9** −10.9 ± 3.7* 0.88