Extracellular cold inducible RNA-binding protein mediates binge alcohol-induced brain hypoactivity and impaired cognition in mice

Table 6 Absolute SUV values corrected for plasma glucose concentration. Global SUV values corrected for glucose levels at post-alcohol between WT and CIRP^−/− mice are significant (P = 0.034, unpaired t-test). No group differences were seen in global SUV values in percent changes between pre- and post-saline treatment (P > 0.07, unpaired test)

	Weight (g)	Injected dose (mCi)	Blood glucose (mg/dl)	Global SUV	Global SUV x blood glucose
Cohort 1
WT-baseline	25.2 ± 0.53	0.98 ± 0.21	209 ± 10.0	84.62 ± 5.87	16.84 ± 1.68
WT-post-alcohol	23.6 ± 0.43	0.67 ± 0.10	203 ± 11.9	82.86 ± 8.58	14.88 ± 1.05
WT baseline vs. post-alcohol (P value)	0.029	0.218	0.807	0.780	0.171
KO-baseline	28.6 ± 1.11	1.00 ± 0.20	212 ± 19.0	91.48 ± 7.82	18.90 ± 1.60
KO-post-alcohol	27.8 ± 1.23	0.79 ± 0.11	193 ± 7.80	108.47 ± 9.51	21.18 ± 2.42
KO baseline vs. KO post-alcohol (P value)	0.181	0.348	0.421	0.072	0.528
WT + KO (baseline)	27.0 ± 0.7	0.99 ± 0.14	211 ± 12.0	88.37 ± 4.98	18.08 ± 1.27
WT + KO (post-alcohol)	25.8 ± 0.81	0.73 ± 0.07	198 ± 6.67	96.28 ± 6.90	18.20 ± 1.52
WT + KO baseline vs WT + KO post-alcohol (P value)	0.009	0.113	0.403	0.146	0.991
Cohort 2
WT-baseline	23.60 ± 0.81	0.67 ± 0.04	184 ± 11.8	99.32 ± 10.86	16.41 ± 2.31
WT-post-saline	24.40 ± 0.60	0.83 ± 0.04	175 ± 14.6	67.07 ± 7.09	12.09 ± 0.55
WT baseline vs. post-saline (P value)	0.242	0.09	0.73	0.058	0.211
KO-baseline	23.0 ± 0.55	0.61 ± 0.04	190 ± 12.4	71.80 ± 9.29	12.66 ± 0.56
KO-post-saline	23.4 ± 0.40	0.66 ± 0.11	197 ± 9.5	72.57 ± 4.67	13.58 ± 0.72
KO baseline vs. KO post-saline (P value)	0.374	0.678	0.499	0.934	0.346
WT + KO (baseline)	23.30 ± 0.47	0.64 ± 0.03	187 ± 7.8	85.56 ± 8.15	14.53 ± 1.35
WT + KO (post-saline)	23.90 ± 7.56	0.74 ± 0.23	186 ± 9.0	69.82 ± 4.11	12.83 ± 4.54
WT + KO baseline vs WT + KO post-saline (P value)	0.111	0.135	0.377	0.114	0.322

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