Fig. 1

Pan-cancer genomic and transcriptomic alterations of JAK-STAT pathway genes. Stacked bar charts depict the fraction of altered samples for each of the 40 putative driver genes. Heatmap in the center illustrates the fraction of somatic gains and losses per gene within each cancer type. Heatmap below illustrates differential expression profiles (tumor vs. non-tumor) for each gene. Hierarchical clustering is performed on columns (genes) using Euclidean distance metric. Cancer abbreviations are listed in the Methods section