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Fig. 4 | Molecular Medicine

Fig. 4

From: An immunoevasive strategy through clinically-relevant pan-cancer genomic and transcriptomic alterations of JAK-STAT signaling components

Fig. 4

Aberrant JAK-STAT signaling drives malignant progression through crosstalk with other oncogenic pathways. a Venn diagram depicts the number of overlapping differentially expressed genes (DEGs) in five cohorts. Differential expression analyses are performed between patients stratified into the 4th and 1st survival quartiles using the JAK-STAT signature in five cancer cohorts. b Functional enrichment analyses are performed by mapping DEGs to the Gene Ontology and KEGG databases. Mapping of DEGs to ENCODE and ChEA databases identify enriched transcription factor binding associated with DEGs. c Somatic copy number alteration frequencies for DEGs identified from enriched pathways in B. Heatmaps depict the fraction of somatic gains and losses for DEGs found within five oncogenic pathways. Only genes that are altered in more than 10% of samples within each tumor type are shown

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Molecular Medicine

ISSN: 1528-3658