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Fig. 6 | Molecular Medicine

Fig. 6

From: An immunoevasive strategy through clinically-relevant pan-cancer genomic and transcriptomic alterations of JAK-STAT signaling components

Fig. 6

Tumors with hyperactive JAK-STAT signaling are hypoimmunogenic. a Scatter plots depict significant positive correlations between 28-gene and regulatory T cell (Treg) scores in glioma and renal cancer patients. Patients are grouped into four categories based on median 28-gene and Treg scores. Density plots at the x- and y-axes show the distribution of 28-gene and Treg scores. b Kaplan-Meier analyses are performed on the four patient groups to determine the ability of the combined JAK-STAT-Treg model in determining overall survival in glioma histological subtypes and renal cancer. P values are obtained from log-rank tests. c Table inset shows univariate Cox proportional hazards analyses of the relationship between JAK-STAT signaling and anti-tumor immunity. Significant P values are highlighted in bold. CI = confidence interval

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Molecular Medicine

ISSN: 1528-3658