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Table 5 Results of the Pathway and GO Biological Process Enrichment Analysis for Several Important Modules

From: Identification of biomarkers in common chronic lung diseases by co-expression networks and drug-target interactions analysis

Disease

Module

Pathway/BP

Term

Adjusted P-value

IPF

Black

Pathway

TNF signaling pathway

2.01E − 014

Cytokine Signaling in Immune system

1.31E − 05

Salmonella infection

4.49E − 09

Legionellosis

1.81E − 04

Inflammatory bowel disease

3.39E − 05

p53 signaling pathway

4.69E − 03

Apoptosis

7.32E − 03

Epithelial cell signaling in Helicobacter pylori infection

2.86E − 02

BP

chronic inflammatory response

2.83E − 07

inflammatory response to wounding

2.83E − 07

cellular response to cytokine stimulus

1.57E − 06

response to interleukin-1

1.74E − 05

positive regulation of cell death

2.26E − 05

fat cell differentiation

1.35E − 04

asthma

Skyblue

Pathway

TGF beta signaling pathway

3.19E − 02

NF-kB Signaling Pathway

3.19E − 02

WNT Signaling Pathway

3.19E − 02

Toll-Like Receptor Pathway

3.19E − 02

Signal transduction through IL1R

3.19E − 02

BP

No Significant

COPD

Brown

Pathway

Tuberculosis

6.85E − 09

Staphylococcus aureus infection

5.2E − 05

Leishmaniasis

8.33E − 06

Pertussis

5.3E − 04

Legionellosis

4.63E − 03

ROS, RNS production in response to bacteria

3.61E − 04

Cell surface interactions at the vascular wall

4.26E − 04

Innate immune system

4.33E − 03

BP

Neutrophil degranulation

3.84E − 023

Regulation of inflammatory response to antigenic stimulus

5.28E − 05

Regulation of innate immune response

9.80E − 05

positive regulation of interleukin-6 secretion

2.52E − 04

Chronic inflammatory response

7.24E − 03

Inflammatory response to wounding

7.24E − 03

Positive regulation of tumor necrosis factor secretion

5.28E − 05