Skip to main content

Table 5 Results of the Pathway and GO Biological Process Enrichment Analysis for Several Important Modules

From: Identification of biomarkers in common chronic lung diseases by co-expression networks and drug-target interactions analysis

DiseaseModulePathway/BPTermAdjusted P-value
IPFBlackPathwayTNF signaling pathway2.01E − 014
Cytokine Signaling in Immune system1.31E − 05
Salmonella infection4.49E − 09
Legionellosis1.81E − 04
Inflammatory bowel disease3.39E − 05
p53 signaling pathway4.69E − 03
Apoptosis7.32E − 03
Epithelial cell signaling in Helicobacter pylori infection2.86E − 02
BPchronic inflammatory response2.83E − 07
inflammatory response to wounding2.83E − 07
cellular response to cytokine stimulus1.57E − 06
response to interleukin-11.74E − 05
positive regulation of cell death2.26E − 05
fat cell differentiation1.35E − 04
asthmaSkybluePathwayTGF beta signaling pathway3.19E − 02
NF-kB Signaling Pathway3.19E − 02
WNT Signaling Pathway3.19E − 02
Toll-Like Receptor Pathway3.19E − 02
Signal transduction through IL1R3.19E − 02
BPNo Significant
COPDBrownPathwayTuberculosis6.85E − 09
Staphylococcus aureus infection5.2E − 05
Leishmaniasis8.33E − 06
Pertussis5.3E − 04
Legionellosis4.63E − 03
ROS, RNS production in response to bacteria3.61E − 04
Cell surface interactions at the vascular wall4.26E − 04
Innate immune system4.33E − 03
BPNeutrophil degranulation3.84E − 023
Regulation of inflammatory response to antigenic stimulus5.28E − 05
Regulation of innate immune response9.80E − 05
positive regulation of interleukin-6 secretion2.52E − 04
Chronic inflammatory response7.24E − 03
Inflammatory response to wounding7.24E − 03
Positive regulation of tumor necrosis factor secretion5.28E − 05