Table 5 Results of the Pathway and GO Biological Process Enrichment Analysis for Several Important Modules
Disease | Module | Pathway/BP | Term | Adjusted P-value |
|---|---|---|---|---|
IPF | Black | Pathway | TNF signaling pathway | 2.01E − 014 |
Cytokine Signaling in Immune system | 1.31E − 05 | |||
Salmonella infection | 4.49E − 09 | |||
Legionellosis | 1.81E − 04 | |||
Inflammatory bowel disease | 3.39E − 05 | |||
p53 signaling pathway | 4.69E − 03 | |||
Apoptosis | 7.32E − 03 | |||
Epithelial cell signaling in Helicobacter pylori infection | 2.86E − 02 | |||
BP | chronic inflammatory response | 2.83E − 07 | ||
inflammatory response to wounding | 2.83E − 07 | |||
cellular response to cytokine stimulus | 1.57E − 06 | |||
response to interleukin-1 | 1.74E − 05 | |||
positive regulation of cell death | 2.26E − 05 | |||
fat cell differentiation | 1.35E − 04 | |||
asthma | Skyblue | Pathway | TGF beta signaling pathway | 3.19E − 02 |
NF-kB Signaling Pathway | 3.19E − 02 | |||
WNT Signaling Pathway | 3.19E − 02 | |||
Toll-Like Receptor Pathway | 3.19E − 02 | |||
Signal transduction through IL1R | 3.19E − 02 | |||
BP | No Significant | – | ||
COPD | Brown | Pathway | Tuberculosis | 6.85E − 09 |
Staphylococcus aureus infection | 5.2E − 05 | |||
Leishmaniasis | 8.33E − 06 | |||
Pertussis | 5.3E − 04 | |||
Legionellosis | 4.63E − 03 | |||
ROS, RNS production in response to bacteria | 3.61E − 04 | |||
Cell surface interactions at the vascular wall | 4.26E − 04 | |||
Innate immune system | 4.33E − 03 | |||
BP | Neutrophil degranulation | 3.84E − 023 | ||
Regulation of inflammatory response to antigenic stimulus | 5.28E − 05 | |||
Regulation of innate immune response | 9.80E − 05 | |||
positive regulation of interleukin-6 secretion | 2.52E − 04 | |||
Chronic inflammatory response | 7.24E − 03 | |||
Inflammatory response to wounding | 7.24E − 03 | |||
Positive regulation of tumor necrosis factor secretion | 5.28E − 05 |