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Fig. 5 | Molecular Medicine

Fig. 5

From: microRNA-195 attenuates neuronal apoptosis in rats with ischemic stroke through inhibiting KLF5-mediated activation of the JNK signaling pathway

Fig. 5

Overexpression of miR-195 enhanced GAP-43 and SYP expression on GAP-43 and SYP expression, thus enhancing neuronal growth, development, axonal regeneration and synaptic remodeling. a Immunohistochemical staining results (200 ×) and the OD value presented by histogram of GAP-43 in each group; b The immunohistochemical staining results (200 ×) and the OD value presented by histogram of SYP in each group; c Western blot analysis of the protein band graph of GAP-43 and SYP and their protein expressions relative to GAPDH presented by histogram; *, p < 0.05, compared with the control group; #, p < 0.05, compared with the WT-MCAO group; MCAO, middle cerebral artery occlusion; miR-195, microRNA-195; WT, wild type; KLF5, Kruppel-like factor 5; OD, optical density; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GAP-43, growth associated protein-43; SYP, synaptophysin

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