Fig. 6
From: TFPI2 suppresses breast cancer progression through inhibiting TWIST-integrin α5 pathway
TFPI2 over-expression inhibited in vivo breast cancer tumor growth. a Transfection efficiency of Ad-pcDNA 3.1-TFPI2 in nude mice, suggesting up-regulation in mice injected with Ad-pcDNA 3.1-TFPI2. ** represents Ad-pcDNA 3.1-TFPI2 vs. Ad-pcDNA 3.1-NC, p < 0.01. b Injection of Ad-pcDNA 3.1-TFPI2 inhibited breast cancer tumor growth and volume. * represents Ad-pcDNA 3.1-TFPI2 vs. Ad-pcDNA 3.1-NC, p < 0.05. c Immunohistochemistry analysis of TFPI2 and TWIST1 in tissues of mice intratumoral injected with Ad-pcDNA 3.1-TFPI2 or Ad-pcDNA 3.1-NC, suggesting up-regulation of TFPI2 and down-regulation of TWIST1 in mice injected with Ad-pcDNA 3.1-TFPI2. d Injection of Ad-pcDNA 3.1-TFPI2 promoted on proteins expression of TFPI2, while inhibited TWIST1 and integrin α5 in xenograft tumor mice