Fig. 3

Circulating fibrocytes in human pneumonia and ARDS. a Change over time in the number of total fibrocytes (CD45+ Col1+) and activated fibrocytes staining for phosphorylated SMAD-2 or − 3 (CD45+ Col1+ pSMAD2/3+) or expressing alpha-smooth muscle actin (CD45+ Col1+ α-SMA+) during the course of ARDS. Each line represents one subject. b Comparison of peak total fibrocytes (CD45+ Col1+) and activated fibrocytes (CD45+ Col1+ pSMAD2/3+ and CD45+ Col1+ α-SMA+). Each dot represents one subject; bold horizontal lines indicate the median, and light horizontal lines represent the 25th and 75th percentiles. Red dots indicate patients that required mechanical ventilation; open dots indicate patients that required vasopressor support. *, p < 0.05; **, p < 0.01, ****, p < 0.0001 by Kruskal-Wallis test