Fig. 3

Mutational spectrum of TP53 DNA binding domain. Mutational spectrum of TP53 DNA binding domain. a Frequency of TP53 DNA binding domain mutations observed by cBioPortal. The red circle is the p.A138V mutation identified in 17% of all TP53 mutations. b Patients (n = 35) with observed TP53 mutations (i.e. 38% of total samples). In the sample row, sky coloured columns are the samples studied in targeted exome sequencing (NGS) and white columns are the samples studied in Sanger sequencing methods. The brown boxes in the TP53 p.A138V row indicate presence of p.A138V mutations in the samples. The colours of the boxes in the demography and clinicopathological characteristics were explained in the pictures below the main picture