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Fig. 5 | Molecular Medicine

Fig. 5

From: RETRACTED ARTICLE: WRN inhibits oxidative stress-induced apoptosis of human lensepithelial cells through ATM/p53 signaling pathway and its expression is downregulated by DNA methylation

Fig. 5

WRN overexpression inhibits ATM/p53 signaling pathway. SRA01/04 cells were transfected with pcDNA3.1-WRN or pcDNA3.1-NC, and then the modified SRA01/04 cells were treated with 100 μM H2O2. a WB was performed to detect the expression of p-ATM, ATM, p53, p-p53, p21, Bax, PUMA and NOXA in the modified SRA01/04 cells. SRA01/04 cells were consecutively treated with 100 μM H2O2 and 5-Aza-CdR. b WB was performed to estimate the expression of p-ATM, ATM, p53, p-p53, p21, Bax, PUMA and NOXA in the modified SRA01/04 cells.(**P < 0.01 compared with the Control group, ##P < 0.01 compared with the H2O2 + Vector group, $P < 0.05 compared with the H2O2 group, $$P < 0.01 compared with the H2O2 group)

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Molecular Medicine

ISSN: 1528-3658