Fig. 7

Loss of caspase-1/11 in addition to CQ results in diminished tetanic peak force Peak force measurements in peroneal nerve after tetanic stimulation at indicated frequencies (Hz) for each mouse in (a) C57Bl/6 J (WT) mice treated with PBS or CQ;*p < 0.05: PBS:CQ at 10 Hz, N = 5 PBS and 5 CQ B; or (b) Caspase-1/11KO mice treated with PBS or CQ; p < 0.05 PBS:CQ 100 Hz, **p < 0.01 PBS:CQ 120 Hz; ***p < 0.001 PBS:CQ 150 Hz and 180 Hz, N = 5 PBS and 5 CQ; (c) ½ relaxation time (RT) and (d) time to peak contraction in C57Bl/6/J and caspase-1/11KO after PBS or CQ treatment (C *p < 0.05; D *p = 0.003; **p < 0.001)