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Table 2 Treatable genetic variants and level of clinical utility

From: Genetic profiling of primary and secondary tumors from patients with lung adenocarcinoma and bone metastases reveals targeted therapy options

Patient Gene Tumor genetic variants (copy number) Treatment options
1° tumor 2° tumor Druga Level of clinical utility
P1 EGFR E746_A750delELREA (1) E746_A750delELREA (1) Gefitinib Level A
P2 EGFR E746_A750delELREA (1) E746_A750delELREA (2) Gefitinib Level A
P3 EGFR E746_A750delELREA (6) E746_A750delELREA (5) Gefitinib Level A
  Amplification Amplification Erlotinib Level B
P4 EGFR L747_A750delinsP (1) L747_A750delinsP (1) Gefitinib Level A
P5 EGFR E746_A750delELREA (0.1) E746_A750delELREA (2) Gefitinib Level A
P6 EGFR E746_A750delELREA (1) E746_A750delELREA (9) Gefitinib Level A
   No amplification Amplification Erlotinib Level B
  TP53 Negative Q331X (2) AZD1775 Level D
P7 EGFR L858R (2) L858R (3) Gefitinib Level A
P8 EGFR L858R (5) L858R (4) Gefitinib Level A
P9 EGFR L858R (5) L858R (6) Erlotinib Level A
   Amplification Amplification Erlotinib Level B
  ATM W3052X (2) W3052X (2) Olaparib Level D
P10 EGFR Negative L858R (4) Osimertinib Level A
  CDK4 No amplification Amplification (17) Abemaciclib Level B
P11 EGFR Negative L858R (2) Gefitinib Level A
P12 EGFR G719S (5) G719S (5) Osimertinib Level B
  Amplification Amplification Erlotinib Level B
TP53 R196X (2) R196X (2) AZD1775 Level D
P13 EGFR L861Q (2) L861Q (3) Gefitinib Level A
TP53 R248W (2) R248W (2) AZD1775 Level D
P14 ALK Fusion (0.3) Fusion (0.2) Crizotinib Level A
P15 TP53 F134Pfs (1) F134Pfs (1) AZD1775 Level D
FGFR1 Amplification (5) Amplification (6) Dovitinib Level D
P16 FGFR3 R248C (0.1) Negative Dovitinib Level D
KRAS Negative G12D (1) Cobimetinib Level D
P17 KRAS G12C (1) G12C (1) AMG-510 Level B
  1. aDrugs shown in normal text represent the initial therapy based on ARMS-PCR genetic test. Drugs shown in bold text represent potential alternative therapies revealed by capSMART test. Amplification of gene variants or normal gene sequences was defined by a copy number of > 5