The MC4R SNPs, their haplotypes and gene-environment interactions on the risk of obesity

Table 1 Comparison of general characteristics between control and obesity groups

Parameter	Control	Obesity	t (x²)	P
Number	978	858
Age (years)^a	55.38 ± 15.33	56.29 ± 14.25	−1.323	0.186
Body mass index (kgm²)	20.01 ± 1.48	27.62 ± 3.07	−66.13	< 0.001
Waist circumference (cm)	71.51 ± 6.487	87.52 ± 8.14	−46.264	< 0.001
Systolic blood pressure (mmHg)	131.49 ± 23.28	137.83 ± 22.79	−5.88	< 0.001
Diastolic blood pressure (mmHg)	80.64 ± 12.36	85.57 ± 13.67	−8.063	< 0.001
Glucose (mmol/L)	6.17 ± 1.37	6.24 ± 1.32	−1.283	0.200
TC (mmol/L)	4.89 ± 0.98	5.09 ± 0.93	−4.607	< 0.001
TG (mmol/L)^b	1.17 (0.93)	1.63 (1.22)	−14.095	< 0.001
HDL-C (mmol/L)	1.30 ± 0.29	1.25 ± 0.26	3.792	< 0.001
LDL-C (mmol/L)	3.10 ± 0.45	3.18 ± 0.50	−3.695	< 0.001
Male/female^c	450/528	395/463	0.000	0.991
Smoking status [n (%)]
Non-smoker	772 (78.9)	637 (74.2)
Smoker	206 (21.1)	221 (25.8)	5.643	0.018
Alcohol consumption [n (%)]
Non-drinker	795 (81.3)	686 (80.0)
Drinker	183 (18.7)	172 (20.0)	0.522	0.470

TC Total cholesterol, TG Triglyceride, LDL-C Low-density lipoprotein cholesterol, HDL-C High-density lipoprotein cholesterol
^aMean ± SD was detected by t-test
^bBecause of non-normal distribution, triglyceride value was presented as median (interquartile range), the discrepancy between the two groups was detected by the Wilcoxon-Mann-Whitney test
^cDifference of classified Data was determined as Chi-square test

ISSN: 1528-3658