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Table 2 The correlation between the MC4R polymorphisms and the risk of obesity [n (%)]

From: The MC4R SNPs, their haplotypes and gene-environment interactions on the risk of obesity

SNP

Genotype

Control

(n = 978)

Obesity

(n = 858)

χ2

P

Adjusted OR

(95% CI)

*P

rs17782313 T > C

TT

823 (84.2)

633 (73.8)

29.974

<  0.001

1

–

CT+ CC

155 (15.8)

225 (26.2)

  

1.428 (1.066–2.061)

0.019

MAF

163 (8.3)

237 (13.8)

28.258

<  0.001

  

PHWE

0.613

0.210

    

rs476828 T > C

TT

780 (79.8)

582 (67.8)

33.921

<  0.001

1

–

CT+ CC

198 (20.2)

276 (32.2)

  

1.585 (1.176–2.136)

0.003

MAF

213 (10.9)

293 (17.1)

29.431

<  0.001

  

PHWE

0.262

0.053

    

rs12970134 G > A

GG

765 (78.2)

606 (70.6)

13.927

<  0.001

1

–

AG+ AA

213 (21.8)

252 (29.4)

  

1.253 (0.924–1.698)

0.147

MAF

224 (11.5)

266 (15.5)

12.961

<  0.001

  

PHWE

0.565

0.085

    
  1. MC4R The melanocortin 4 receptor gene, MAF Minor allele frequency, HWE Hardy-Weinberg equilibrium. P was detected as Chi-square test probability. *P was determined as Logistic test probability
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Molecular Medicine

ISSN: 1528-3658