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Fig. 4 | Molecular Medicine

Fig. 4

From: Exosomal miR-223 derived from natural killer cells inhibits hepatic stellate cell activation by suppressing autophagy

Fig. 4

NK-Exo attenuated TGF-β1-induced HSC activation by inhibiting ATG7 expression. Cell proliferation ratio determined by CCK-8 assay (a), the mRNA (b) and protein (c) levels of α-SMA and CoL1A1 in LX-2 cells transfected with ATG7 overexpression vector/empty vector followed by treatment with NK-Exo/PBS in the presence of TGF-β1. *P < 0.05, **P < 0.01 vs. TGF-β1 + Vector+PBS; #P < 0.05, ##P < 0.01 vs. TGF-β1 + Vector+NK-Exo. The data are presented as the mean ± standard deviation (n = 3)

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Molecular Medicine

ISSN: 1528-3658