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Fig. 5 | Molecular Medicine

Fig. 5

From: SHP2 inhibitor PHPS1 ameliorates acute kidney injury by Erk1/2-STAT3 signaling in a combined murine hemorrhage followed by septic challenge model

Fig. 5

Effects of PHPS1 on systemic plasma levels of inflammatory cytokine/chemokine produced after Hem/CLP. The plasma levels of IL-6 (a), IL-10 (b), TNF-α (c), MIP-2 (d) and KC (e) in the vehicle or the PHPS1 treated Hem/CLP mice were increased compared to the Sham animals. However, this Hem/CLP-induced increase was markedly suppressed by PHPS1 treatment for IL-10, TNF-α and MIP-2, but not IL-6 and KC levels. *P < 0.05, versus Sham (S/S); # P < 0.05, PHPS1 treated group (Hem/CLP + PHPS1) versus Hem/CLP + vehicle (Hem/CLP). One-way ANOVA and a Student-Newman-Keuls’ test, Mean ± SD; n = 6 mice/group

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Molecular Medicine

ISSN: 1528-3658