Skip to main content
Fig. 1 | Molecular Medicine

Fig. 1

From: The crosstalk of ABCA1 and ANXA1: a potential mechanism for protection against atherosclerosis

Fig. 1

The mechanism and function of the ABCA1 interaction with ANXA1. ANXA1 serves as an inhibitory protein of PLA2 () and increases the expression of PPARγ (), IL-10 (). The expression of ABCA1 is increased by the PLA2 inhibitory protein (), PPARγ (), IL-10 (). Therefore, ANXA1 increases ABCA1 expression and then combines with apoA-I to promote cholesterol efflux and anti-inflammatory effects (). However, this function has not been investigated and requires further study. ABCA1 increases ANXA1 expression by binding to apoA-I, controlling the ERK, p38 MAPK, AKT, and PKC pathways (), and PPARγ increases ANXA1 expression by binding to the promoter of ANXA1 (). ABCA1 transports ANXA1 and thereby mediates ANXA1 efflux and release (⑩), thereby promoting the functions of ANXA1, including anti-inflammatory effects, cholesterol transport, exosomes, microparticle secretion, apoptotic cell clearance, and immunogenic cell death (⑪). Thus, ABCA1, PPARγ, and ANXA1 may form a feedback loop and regulate each other. However, this interaction among ABCA1, PPARγ, and ANXA1 requires further study

Back to article page