Fig. 1
From: The crosstalk of ABCA1 and ANXA1: a potential mechanism for protection against atherosclerosis
The mechanism and function of the ABCA1 interaction with ANXA1. ANXA1 serves as an inhibitory protein of PLA2 (①) and increases the expression of PPARγ (②), IL-10 (③). The expression of ABCA1 is increased by the PLA2 inhibitory protein (④), PPARγ (⑤), IL-10 (⑥). Therefore, ANXA1 increases ABCA1 expression and then combines with apoA-I to promote cholesterol efflux and anti-inflammatory effects (⑦). However, this function has not been investigated and requires further study. ABCA1 increases ANXA1 expression by binding to apoA-I, controlling the ERK, p38 MAPK, AKT, and PKC pathways (⑧), and PPARγ increases ANXA1 expression by binding to the promoter of ANXA1 (⑨). ABCA1 transports ANXA1 and thereby mediates ANXA1 efflux and release (⑩), thereby promoting the functions of ANXA1, including anti-inflammatory effects, cholesterol transport, exosomes, microparticle secretion, apoptotic cell clearance, and immunogenic cell death (⑪). Thus, ABCA1, PPARγ, and ANXA1 may form a feedback loop and regulate each other. However, this interaction among ABCA1, PPARγ, and ANXA1 requires further study