Fig. 5

Bone-targeted shHCG18 improves trabecular bone phenotypes in HU mice. a Representative images of micro-CT 2D sections and 3D reconstruction of distal femurs of mice in the indicated groups (n = 5). b Micro-CT measurement of bone mineral density (BMD), the ratio of bone volume to total volume (BV/TV), the ratio of bone surface to bone volume (BS/BV), trabecular bone number (Tb.N), trabecular thickness (Tb.Th) and trabecular bone pattern factor (Tb.PF) (n = 5). c H&E staining showing trabecular microarchitecture and quantitative analysis of the bone area/total area on the proximal side of the growth plate in the distal femurs of mice in the indicated groups (n = 5). Scale bars: 300 tain. d Representative load deflection curves for the respective groups (n = 5). e The maximum load, stiffness and elastic modulus were calculated (n = 5). All data are the mean ± SD. *P < 0.05