Table 3 Results of statistically overrepresented biological processes and molecular function in set of differentially methylated genes
Description | p-value | Corr p-value | N | Hypermethylated | Hypomethylated |
|---|---|---|---|---|---|
a. Gene Ontology_Biological Processes | |||||
Lipid metabolic process | 6.0610E−33 | 1.0849E−29 | 47 | ABCG1 ACADM ACP6 ACSL6 AHRR CAV1 CPT1A ELOVL3 ELOVL5 ELOVL6 FDFT1 FDPS GPX1 GPX4 HDLBP NR1H2 LDLR LRP1 LRP5 PCSK9 PMVK RXRA SREBF1 SQLE | ABCB4 ACOT1 ACOT7 ACSF2 AGPAT2 AMN CRAT CYP1B1 CYP27B1 CYP51A1 DHCR7 FASN IL6ST INSIG1 LIPA LPL LRP8 MLYCD MCAT PPARD PPARG SLC27A1 STARD3 |
Regulation of lipid biosynthetic process | 1.8237E−6 | 3.4005E−5 | 6 | ABCG1 ACSL6 NR1H2 | DHCR7 FGF19 SLC27A1 |
Negative regulation of lipid biosynthetic process | 6.2381E−3 | 2.5581E−2 | 2 | FGF19 SLC27A1 | |
Fatty acid metabolic process | 9.26E−17 | 2.37E−14 | 19 | ACADM ACSL6 CPT1A ELOVL3 ELOVL5 ELOVL6 PPARA | ACOT1 ACOT7 ACSF2 AMN CRAT FASN LIPA LPL MCAT MLYCD PPARD SLC27A1 |
Cholesterol metabolic process | 6.73E−19 | 6.02E−16 | 16 | ABCG1 FDFT1 FDPS HDLBP LDLR PCSK9 PMVK RXRA SREBF1 SQLE | CYP51A1 DHCR7 LIPA PPARD SREBF2 STARD3 |
Triglyceride metabolic process | 1.02E−08 | 4.81E−07 | 7 | ACSL6 CAV1 CPT1A PCSK9 | IL6ST LIPA LPL |
Cholesterol biosynthetic process | 5.57E−07 | 1.49E−05 | 5 | FDFT1 FDPS PMVK | CYP51A1 DHCR7 |
Regulation of cholesterol storage | 8.89E−09 | 4.42E−07 | 5 | ABCG1 NR1H2 PPARA | LPL PPARG |
Cholesterol transport | 2.01E−07 | 6.09E−06 | 6 | ABCA5 ABCG1 ABCG4 CAV1 LDLR | LIPA |
Cholesterol efflux | 1.00E−05 | 1.50E−04 | 4 | ABCA5 ABCG1 ABCG4 CAV1 | |
Reverse cholesterol transport | 5.57E−03 | 2.37E−02 | 2 | ABCA5 ABCG1 | |
Regulation of cholesterol transport | 4.57E−04 | 3.38E−03 | 3 | NR1H2 LRP1 | PPARG |
Negative regulation of cholesterol storage | 2.72E−08 | 1.08E−06 | 4 | ABCG1 NR1H2 PPARA | PPARG |
Fatty acid biosynthetic process | 1.60E−06 | 3.12E−05 | 7 | ELOVL3 ELOVL5 ELOVL6 | FASN LPL MLYCD MCAT |
Fatty acid transport | 2.46E−08 | 1.05E−06 | 6 | ACSL6 PPARA | PPARD PPARG SLC25A20 SLC27A1 |
Fatty acid beta-oxidation | 1.22E−06 | 2.63E−05 | 5 | ACADM CPT1A | AMN CRAT PPARD |
Regulation of fatty acid oxidation | 2.39E−06 | 4.32E−05 | 5 | CPT1A PPARA | MLYCD PPARG SLC25A20 |
Long-chain fatty acid metabolic process | 1.90E−03 | 1.04E−02 | 2 | ACSL6 | ACOT1 |
Regulation of macrophage derived foam cell differentiation | 1.52E−08 | 6.63E−07 | 6 | ABCA5 ABCG1 NR1H2 PPARA | LPL PPARG |
Low-density lipoprotein receptor metabolic process | 4.37E−05 | 5.00E−04 | 2 | PCSK9 | PPARG |
Plasma lipoprotein particle remodeling | 3.99E−04 | 3.11E−03 | 3 | ABCA5 ABCG1 | LPL |
High-density lipoprotein particle remodeling | 3.77E−03 | 1.75E−02 | 2 | ABCA5 ABCG1 | |
Regulation of steroid metabolic process | 3.09E−03 | 1.52E−02 | 3 | ABCG1 | FGF19 DHCR7 |
Glucose homeostasis | 1.17E−06 | 2.58E−05 | 5 | FOXO3 NCOR2 TCF4 TCF7L2 | PPARG |
Response to glucose stimulus | 6.04E−05 | 6.47E−04 | 4 | EP300 TCF7L2 TCF4 | PPARD |
Regulation of insulin secretion | 4.82E−04 | 3.50E−03 | 3 | CPT1A TCF4 TCF7L2 | |
Carbohydrate homeostasis | 1.17E−06 | 2.58E−05 | 5 | FOXO3 NCOR2 TCF4 TCF7L2 | PPARG |
Regulation of response to stress | 5.02E−05 | 5.65E−04 | 10 | AP2A2 AP2S1 AP2M1 CAV1 GPX4 | FGF19 IL6ST IRAK1 PPARG PRKACA |
Negative regulation of apoptosis | 3.59E−03 | 1.70E−02 | 8 | ANGPTL4 NKX2-6 SIN3A PCSK6 TCF4 TCF7L2 | FGFR1 IRAK1 |
b. Gene Ontology_Molecular Function | |||||
Lipid binding | 2.19E−08 | 3.54E−06 | 15 | ABCG1 AP2A2 AP2M1 CAV1 HDLBP PPARA RXRA S1PR4 | ACOT7 ITPR1 LIPA LPL PPARD PPARG STARD3 |
Receptor binding | 1.99E−06 | 1.16E−04 | 19 | ANGPTL4 CAV1 EP300 LRP1 IL6ST IL13 NCOA2 NCOR2 NR1H2 PCSK9 RXRA TCF4 TCF7L2 TGFB1I1 | CD8A FGF19 IRAK1 LPL PPARG |
Transporter activity | 1.44E−03 | 1.01E−02 | 16 | ABCC1 ABCC9 ABCG1 AMN AP2A2 AP2S1 AP2M1 APC2 KCNJ6 LRP1 SLC27A1 | ABCB4 FASN ITPR1 SLC25A20 STARD3 |
Transcription factor binding | 1.26E−08 | 3.54E−06 | 17 | CTCF GATA4 EP300 LRP1 MED21 NCOA2 NCOR2 NR1H2 RXRA SIN3A TCF4 TCF7L2 TGFB1I1 | NFYC MED7 PPARD PPARG |
Transcription cofactor activity | 1.14E−05 | 4.22E−04 | 11 | CTCF EP300 LRP1 MED21 NCOR2 NCOA2 RXRA SIN3A TGFB1I1 | NFYC MED7 |
Lipoprotein binding | 1.21E−03 | 9.26E−03 | 3 | LDLR LRP1 | LRP8 |