Skip to main content

Table 1 Correlation of KBTBD8 protein level and the malignance grade of the ovarian tissues

From: Downregulation of the ubiquitin ligase KBTBD8 prevented epithelial ovarian cancer progression

Feature KBTBD8 staining scorea Nb p valuec
 −  + ++
Age(years)
 ≤ 48 8 16 11 35 0.037
 > 48 3 17 15 35  
TNM-stage
 – 4 2 6 12 0.03
 TI 6 15 11 32  
 TII 0 10 5 15  
 TIII 1 6 4 11  
Lymph node metasitasis
 Yes 0 6 3 9 0.688
 No 11 27 23 61  
Multifocality
 Yes 0 2 0 2 0.626
 No 11 31 26 68  
Disease grade
 – 9 4 5 18 0.00
 1 1 8 5 14  
 2 1 11 3 15  
 3 0 10 13 23  
TNM stage group
 – 4 2 6 12 0.021
 I 6 15 11 32  
 II 0 8 5 13  
 III 1 6 4 11  
 IV 0 2 0 2  
Percent of positive cells(PP)
 ≤ 50 11 23 2 36 0.00
 > 50 0 10 24 34  
  1. This table was generalized from Additional file 1: Dataset 1. The intensity score of KBTBD8 staining of each array point was standardized as follows: 0, no staining; 1, weak staining; 2, moderate staining; and 3, strong staining. For each array point, at least 500 randomly-picked cells from five random areas were observed and analyzed by two independent professional analyzers to generate a final average score
  2. The proportion score of KBTBD8-stained tumor cells was standardized as follows: 0, < 5% of cells with positive KBTBD8 staining; 1, 5–25%; 2, 25–50%; 3, 50–75%; and 4, > 75%
  3. Next the final score was obtained by the intensity score added together with the proportion score. A final score of 0–1 was defined as (−), while scores of 1–2, 3–4, and 5–6 were considered (+), (++) and (+++), respectively
  4. aThe KBTBD8 antibody staining Score method is detailed as follow
  5. bN stands for the number of cases
  6. cp values were calculated by Kruskal–Wallis H test tests. A value of p < 0.05 was considered statistically significant