|
Feature
|
KBTBD8 staining scorea
|
Nb
|
p valuec
|
|---|
|
−
|
+
|
++
|
|---|
|
Age(years)
|
|
≤ 48
|
8
|
16
|
11
|
35
|
0.037
|
|
> 48
|
3
|
17
|
15
|
35
| |
|
TNM-stage
|
|
–
|
4
|
2
|
6
|
12
|
0.03
|
|
TI
|
6
|
15
|
11
|
32
| |
|
TII
|
0
|
10
|
5
|
15
| |
|
TIII
|
1
|
6
|
4
|
11
| |
|
Lymph node metasitasis
|
|
Yes
|
0
|
6
|
3
|
9
|
0.688
|
|
No
|
11
|
27
|
23
|
61
| |
|
Multifocality
|
|
Yes
|
0
|
2
|
0
|
2
|
0.626
|
|
No
|
11
|
31
|
26
|
68
| |
|
Disease grade
|
|
–
|
9
|
4
|
5
|
18
|
0.00
|
|
1
|
1
|
8
|
5
|
14
| |
|
2
|
1
|
11
|
3
|
15
| |
|
3
|
0
|
10
|
13
|
23
| |
|
TNM stage group
|
|
–
|
4
|
2
|
6
|
12
|
0.021
|
|
I
|
6
|
15
|
11
|
32
| |
|
II
|
0
|
8
|
5
|
13
| |
|
III
|
1
|
6
|
4
|
11
| |
|
IV
|
0
|
2
|
0
|
2
| |
|
Percent of positive cells(PP)
|
|
≤ 50
|
11
|
23
|
2
|
36
|
0.00
|
|
> 50
|
0
|
10
|
24
|
34
| |
- This table was generalized from Additional file 1: Dataset 1. The intensity score of KBTBD8 staining of each array point was standardized as follows: 0, no staining; 1, weak staining; 2, moderate staining; and 3, strong staining. For each array point, at least 500 randomly-picked cells from five random areas were observed and analyzed by two independent professional analyzers to generate a final average score
- The proportion score of KBTBD8-stained tumor cells was standardized as follows: 0, < 5% of cells with positive KBTBD8 staining; 1, 5–25%; 2, 25–50%; 3, 50–75%; and 4, > 75%
- Next the final score was obtained by the intensity score added together with the proportion score. A final score of 0–1 was defined as (−), while scores of 1–2, 3–4, and 5–6 were considered (+), (++) and (+++), respectively
- aThe KBTBD8 antibody staining Score method is detailed as follow
- bN stands for the number of cases
- cp values were calculated by Kruskal–Wallis H test tests. A value of p < 0.05 was considered statistically significant
