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Fig. 4 | Molecular Medicine

Fig. 4

From: Electroacupuncture reduces scopolamine-induced amnesia via mediating the miR-210/SIN3A and miR-183/SIN3A signaling pathway

Fig. 4

EA treatment restored up-regulated rno-miR-183-5p and rno-miR-210-3p, and down-regulated SIN3A mRNA and protein in SIA rats (a–c Real-time PCR; d Western blot; e IHC analysis; Technical repeats n = 3; Animal number in each group N = 6; *p value < 0.05, vs sham group; **p value < 0.05, vs. SIA group). a Rno-miR-183-5p expression was the lowest in SIA rats, while EA treatment partly restored the rno-miR-183-5p expression in SIA rats. b Rno-miR-210-3p expression was the lowest in SIA rats, while EA treatment partly restored the rno-miR-210-3p expression in SIA rats. c The level of SIN3A mRNA was the highest in SIA rats, while EA treatment partly restored the SIN3A mRNA expression in SIA rats. d The level of SIN3A protein was the highest in SIA rats, while EA treatment partly restored the SIN3A protein level in SIA rats. e EA treatment reduced SIN3A expression in the hippocampus of SIA rats

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Molecular Medicine

ISSN: 1528-3658