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Fig. 5 | Molecular Medicine

Fig. 5

From: Downregulation of long noncoding RNA DLEU1 attenuates hypersensitivity in chronic constriction injury-induced neuropathic pain in rats by targeting miR-133a-3p/SRPK1 axis

Fig. 5

Overexpression of SRPK1 reversed the effects of silenced DLEU1 on inflammation and neuropathic pain-like behaviors in CCI rats. a The mRNA or protein expression of SRPK1 in CCI rats spinal cord tissues infected with lentivirus encoding SRPK1 at postoperative day 7 was detected by RT-qPCR analysis. N = 8 for each group. b ELISA tested the concentrations of IL‐6, TNF-α and IL‐1β in spinal cord tissues of CCI rats at postoperative day 7. N = 8 for each group. c Paw withdrawal mechanical threshold (PWT) at postoperative days 0, 7, 14 and 21 days. N = 8 for each group. d The thermal hypersensitivity was assessed by paw withdrawal latency (PWL) at postoperative days 0, 7, 14 and 21 days. N = 8 for each group. *p < 0.05, &p < 0.05

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Molecular Medicine

ISSN: 1528-3658