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Fig. 10 | Molecular Medicine

Fig. 10

From: Acupuncture protects against cerebral ischemia–reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis

Fig. 10

A simple diagrammatic schema. Acupuncture alleviates cerebral ischemia–reperfusion (I/R) injury-induced activation of endoplasmic reticulum (ER) stress as evidenced by inhibiting the expression of glucose-regulated protein 78 (GRP78), transcription factor 6 (ATF-6), transcription factor 4 (ATF-4), C/EBP-homologous protein (CHOP), and phosphorylation of PKR-like ER kinase (PERK), inositol-requiring protein 1 (IRE1), and α unit of eukaryotic initiation factor 2 (eIF2α), which subsequently restrained ER-stress dependent autophagy via down-regulating LC3II/I ratio and Beclin-1 levels and up-regulating p62 level. Acupuncture also suppressed ER-stress-mediated apoptosis via decreasing Bcl-2 Associated X Protein (Bax), cleaved caspase-12, cleaved caspase-9, cleaved caspase-3, cleaved poly ADP-ribose polymerase (PARP) expression, and increasing B-cell lymphoma-2 (Bcl-2) expression

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Molecular Medicine

ISSN: 1528-3658