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Fig. 1 | Molecular Medicine

Fig. 1

From: Increased H3K4me3 methylation and decreased miR-7113-5p expression lead to enhanced Wnt/β-catenin signaling in immune cells from PTSD patients leading to inflammatory phenotype

Fig. 1

RNA-seq analysis using PBMCs from PTSD and control participants. Five control and 5 PTSD patient samples each were included for the analysis using total RNA from PBMCs as described previously by us (Zhou et al. 2014). The expression levels of different genes including WNT ligands (a) and WNT signaling pathway (b), shown as FPKM values. Black and grey bars represent control and PTSD samples, respectively. The values above the bars indicate log2 fold change as obtained after RNAseq data analysis. c Expression level of TLE3 in control and PTSD patients. The transcript level of WNT10B and CTNNB1was validated by qRT-PCR in 24 control and PTSD samples each (d, e). The p values were derived from the RNA-seq data analysis tool (a–c) and Student’s t test (d, e)

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Molecular Medicine

ISSN: 1528-3658