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Fig. 2 | Molecular Medicine

Fig. 2

From: Increased H3K4me3 methylation and decreased miR-7113-5p expression lead to enhanced Wnt/β-catenin signaling in immune cells from PTSD patients leading to inflammatory phenotype

Fig. 2

ChIP-seq analysis for H3K4me3 marks. Six PTSD and 6 control samples were analyzed. In panel (a), a representative H3K4me3 ChIP-seq signal obtained after visualization of the sequencing data in Integrated Genome Browser (IGB) for human chromosome 19 is shown. b H3K4me3 signal around 5 genes of the WNT signaling pathway in 6 controls and 6 PTSD samples. One horizontal line represents a sample. c KDM5B was knocked down by siRNA in THP1 cells and confirmed by qRT-PCR after 72 h. The bar graph shows level of KDM5B transcripts in siRNA transfected cells. d WNT10B transcript level in KDM5B knocked down cells after 72 h. (RE relative expression)

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Molecular Medicine

ISSN: 1528-3658