Fig. 6
From: Elevated MST1 leads to apoptosis via depletion of YAP1 in cardiomyocytes exposed to high glucose
Survivin targeted by yes-associated protein 1 (YAP1) in response to high glucose (HG) in cardiomyocytes. Western blotting showing: a Survivin and CyclinD1 protein expression in cardiomyocytes after 2 days of HG treatment (experiments were replicated 3 times); effect of YAP1 overexpression on b upregulation of Survivin protein (n = 3) and c suppression of HG-mediated downregulation of Survivin (n = 3). d Hoechst 33,342 staining showing inhibitory effect of YM155 on the capacity of YAP1 to suppress HG-induced apoptosis; *P < 0.05 and **P < 0.01 compared with the untreated group; #P < 0.05 and ##P < 0.01 compared with the HG-treated group (n = 3); $P < 0.05 and $$P < 0.01 compared with the YAP1 plasmid-transfected group. e Sketch diagram showing the regulatory mechanism of the mammalian sterile 20-like kinase 1 (MST1)/large tumor suppressor kinase 1 and 2 (LATS1/2)/YAP1/Survivin pathway in modulating cardiomyocyte apoptosis and maternal diabetes-induced heart defects