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Fig. 7 | Molecular Medicine

Fig. 7

From: ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy

Fig. 7

FOXC1 activates ELAVL1 during H/R. a–c Relative mRNA and protein levels of FOXC1 in cells upon control or H/R exposure. d–f Relative mRNA and protein levels of FOXC1 and ELAVL1 in si-FOXC1 transfected cells following H/R. g Relative α-Satellite level pulled down by FOXC1 antibody or control IgG antibody during control or H/R. h Relative ELAVL1 level pulled down by FOXC1 antibody or control IgG antibody during control or H/R. i FOXC1 binding motif provided by the JASPAR database. j Relative luciferase activities of empty vectors or vectors containing E1, E2, or both under baseline. k Relative luciferase activities of empty vectors or vectors containing E1, E2, or both following H/R exposure. The results were presented as the mean ± SD. n = 3; *P < 0.05, **P < 0.01, ***P < 0.001

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Molecular Medicine

ISSN: 1528-3658