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Fig. 5 | Molecular Medicine

Fig. 5

From: Administration of zoledronic acid alleviates osteoporosis in HIV patients by suppressing osteoclastogenesis via regulating RANKL expression

Fig. 5

MiR-302, miR-101 and miR-145 suppressed the expression of PRKACB, RANKL and SMAD3 through binding to their 3′ UTR, respectively (*P value < 0.05 vs. NC group). a Sequence analysis indicated potential binding of miR-302 to the 3′ UTR of PRKACB. b The luciferase activity of wild type PRKACB vector was suppressed by miR-302 in human osteoclast precursor cells. c Sequence analysis indicated potential binding of miR-101 to the 3′ UTR of RANKL. d The luciferase activity of wild type RANKL vector was suppressed by miR-101 in human osteoclast precursor cells. e Sequence analysis indicated potential binding of miR-145 to the 3′ UTR of SMAD3. f The luciferase activity of wild type SMAD3 vector was suppressed by miR-145 in human osteoclast precursor cells

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Molecular Medicine

ISSN: 1528-3658