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Fig. 5 | Molecular Medicine

Fig. 5

From: Clara cell 16 KDa protein mitigates house dust mite-induced airway inflammation and damage via regulating airway epithelial cell apoptosis in a manner dependent on HMGB1-mediated signaling inhibition

Fig. 5

HMGB1 deficiency alleviates airway damage in HDM-induced mice. Ad-GFP and Ad-sh-HMGB1 mice were generated by intratracheally delivery of recombinant adenovirus, and then subjected to saline (negative control) or HDM exposure. a Relative mRNA levels of HMGB1 in mouse lungs. b Histopathological analysis of lung tissue sections by H&E or PAS staining. c The caspase-3 activities of the lungs in different treatment groups. Data are expressed as ##p < 0.05 vs. control + Ad-GFP group; *p < 0.05 vs. HDM + Ad-GFP group; **p < 0.01 vs. HDM + Ad-GFP group

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Molecular Medicine

ISSN: 1528-3658