Fig. 5
From: Nanocell-mediated delivery of miR-34a counteracts temozolomide resistance in glioblastoma
Significant heterogeneity exists in the expression of resistance mechanisms in glioblastoma. a Expression of resistance genes in different glioblastoma subtypes. Log2 mRNA expression of resistance genes in classical (orange), mesenchymal (green) and proneural (blue) subtypes. Tukey HSD test was used to assess statistical significance. ***p < 0.001; **p < 0.01; *p < 0.05. Horizontal lines refer to the groups being compared for statistical analysis. CL: classical glioblastoma subtype, MS: mesenchymal glioblastoma subtype, PN: proneural glioblastoma subtype. b Different therapeutic resistance mechanisms are enriched in distinct spatial compartments of glioblastoma. Heatmap of relative mRNA expression of resistance genes from different tumor areas. LE: leading edge, IT: infiltrating tumor, CT: cellular tumor, PPC: pseudo-palisading cells, MVP: microvascular proliferation