Variables | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Age (< 37 vs. ≥ 37 years) | 0.530 (0.266–1.056) | 0.071 |  |  |
Figo stage (I vs. II vs. III vs. IV) | 1.941 (1.330–2.832) | 0.001 | 1.055 (0.690–1.614) | 0.804 |
Tumor size (cm) (< 4.5 vs. ≥ 4.5) | 2.303 (1.280–4.145) | 0.005 | 1.138 (0.581–2.228) | 0.707 |
Histological type (HPVA vs. NHPVA) | 0.310 (0.162–0.592) | 0.000 | 0.536 (0.241–1.192) | 0.126 |
Differentiation (Well vs. Moderate vs. Poor) | 1.266 (0.778–2.062) | 0.343 |  |  |
Stromal invasion (< 1/3 vs.1/3–2/3 vs. ≥ 2/3) | 2.363 (1.557–3.585) | 0.000 | 1.468 (0.908–2.373) | 0.117 |
Nerve invasion (Negative vs. Positive) | 2.846 (1.426–5.680) | 0.003 | 0.659 (0.275–1.581) | 0.350 |
LVI (None vs. Focal vs. Moderate vs. Extensive) | 1.600 (1.214–2.108) | 0.001 | 1.367 (0.975–1.917) | 0.070 |
LNM (Negative vs. Positive) | 4.631 (2.685–7.987) | 0.000 | 2.665 (1.350–5.262) | 0.005 |
Parametrium invasion (Negative vs. Positive) | 4.099 (1.987–8.456) | 0.000 | 1.495 (0.635–3.523) | 0.357 |
Surgical margin (Negative vs. Positive) | 2.687 (1.264–5.712) | 0.010 | 1.019 (0.435–2.390) | 0.965 |
HPV subtype (HPV 16 vs. HPV18 vs. Other types vs. Not available vs. Negative) | 0.846 (0.637–1.123) | 0.247 |  |  |
MMR (dMMR vs. pMMR) | 0.969 (0.350–2.686) | 0.952 |  |  |
P16 (Negative vs. Positive) | 0.335 (0.172–0.652) | 0.001 | 0.669 (0.293–1.530) | 0.341 |
Ki67 (< 12.5vs. ≥ 12.5) | 0.784 (0.431–1.426) | 0.426 |  |  |
TACC3 (Low vs. High) | 2.621 (1.517–4.530) | 0.001 | 2.265 (1.232–4.166) | 0.009 |