Fig. 1From: Therapeutic administration of etoposide coincides with reduced systemic HMGB1 levels in macrophage activation syndromeHigh systemic HMGB1 levels in MAS patients. Plasma HMGB1 levels measured by ELISA were markedly increased during severe MAS as compared to children with uncomplicated JIA and healthy pediatric controls. The HMGB1 levels in the same cohort of JIA patients and healthy control children have been published previously in (Schierbeck et al. 2013). JIA juvenile idiopathic arthritis, MAS macrophage activation syndrome. *p < 0.05Back to article page