Table 1 Expression and clinical significance of lncRNA TUG1 in human cancer
From: Role of long noncoding RNA taurine‐upregulated gene 1 in cancers
No | Year | Authors | Cancer | Findings | Methods | Marker | References |
|---|---|---|---|---|---|---|---|
1.1 | 2020 | Mai Mohyeldeen, et al. | Hepatocellular carcinoma | Expression of lncRNA TUG1 was down-regulated in viral hepatitis C and viral hepatitis C-associated hepatocellular carcinoma and was closely associated with deregulated liver function and elevated AFP levels | Liver function tests, the antioxidant status, serum AFP and TUG1 | Diagnosis | (Mai et al. 2020) |
1.2 | 2020 | Yang-Hsiang Lin, et al. | Hepatocellular carcinoma | AFP mRNA levels showed strong positive correlations with lncRNA TUG1 and unfavorable prognosis in patients with non-hepatitis B/non-hepatitis C hepatocellular carcinoma | Quantitative real-time polymerase chain reaction (qRT-PCR) | Progression | (Lin et al. 2020) |
1.3 | 2020 | El-Khazragy Nashwa, et al. | Ovarian cancer | The expression of lncRNA TUG1 was down-regulated in cisplatin-resistant tissues | qRT-PCR | Cisplatin resistance | (Nashwa et al. 2020) |
1.4 | 2020 | Abdolmaleki Feraydoon, et al. | Bladder cancer | Expression of lncRNA TUG1 was down-regulated in bladder cancer tissues | qRT-PCR | Diagnosis | (Feraydoon et al. 2020) |
1.5 | 2019 | Qingqing Yin, et al. | Multiple myeloma | Expression of lncRNA TUG1 was high in multiple myeloma | qRT-PCR | Diagnosis | (Qingqing et al. 2019) |
1.6 | 2019 | Farbod Esfandi, et al. | Non-small cell lung cancer | Expression of lncRNA TUG1 was down-regulated in tumoral tissues obtained from male subjects compared with the corresponding adjacent non-cancerous tissues | qRT-PCR, In silico analyses | Diagnosis | (Farbod and Mohammad 2019) |
1.7 | 2018 | Qi Chen, et al. | Osteosarcoma | Expression of lncRNA TUG1 was high in tumor tissues and it was association with carcinogenesis and progression in osteosarcoma | qRT-PCR | Progression | (Qunli and Qi 2018) |
1.8 | 2018 | Wenfeng Luo, et al. | R/R AML | Expression of lncRNA TUG1 was high in R/R AML patients. It might serve as a potential biomarker for poor prognosis in R/R AML patients treated with CLAG or FLAG based chemotherapy | qRT-PCR, Statistical analysis | Progression | (Luo Wenfeng and Huilan 2018) |
1.9 | 2016 | Lin Jiang, et al. | Esophageal squamous cell carcinoma | Expression of lncRNA TUG1 was high in esophageal squamous cell carcinoma tissues. It was correlated with chemotherapy resistance and might predict a poor prognostic outcome of esophageal squamous cell carcinoma | qRT-PCR | Progression | (Lin et al. 2016) |