Fig. 3
From: CircHYBID regulates hyaluronan metabolism in chondrocytes via hsa-miR-29b-3p/TGF-β1 axis
Differentially expressed circular RNAs (circRNAs) related to hyaluronan (HA) metabolism and characterization of circHYBID. A The expression trends of has-circ-COL3A1, circHYBID, hsa_circ_0006719, hsa_circ_0009125, hsa_circ_0002882, and hsa_circ_0003922 were confirmed by quantitative real-time polymerase chain reaction (PCR). B PCR analysis of circHYBID and its linear isoform HA-binding protein involved in hyaluronan depolymerization (HYBID) using complementary and genomic DNA. GAPDH was used as the linear RNA control. C The back-splice junction of circHYBID was identified by Sanger sequencing. D Correlation scatter plot of the relative expression of circHYBID and the alcian blue score (Pearson’s correlation, r = 0.6349). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001