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Fig. 1 | Molecular Medicine

Fig. 1

From: Anti-tuberculosis chemotherapy alters TNFR2 expression on CD4+ lymphocytes in both drug-sensitive and -resistant tuberculosis: however, only drug-resistant tuberculosis maintains a pro-inflammatory profile after a long time

Fig. 1

cTreg and cTregTNFR + are decreased in DS-TB and DR-TB patients in response to anti-TB therapy. Peripheral mononuclear cells from drug-susceptible (DS-TB) and drug-resistance (DR-TB) tuberculosis patients were obtained at diagnosis time (basal), two months (2 m), and 6 months (6 m) of use of anti-TB therapy, and then they were prepared for flow cytometry. For analysis, a gate of CD3+ CD4+ CD25+ Foxp3+ cells (conventional regulatory T cells, cTreg) was identified. Then, the expression of tmTNF, tmTNFR1 and tmTNFR2 on the cTreg cell surface was evaluated. A The frequency of cTreg cells was obtained at basal, 2 m and 6 m of anti-TB therapy. The frequency of cTreg positive to tmTNF (B), tmTNFR1 (C) and tmTNFR2 (D) was evaluated. DS-TB n = 11, DR-TB n = 7. Bar graphs showing the mean ± SD. One Way ANOVA with Dunn's post-test multiple comparisons tests (*p < 0.05 **p < 0.01)

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Molecular Medicine

ISSN: 1528-3658