Fig. 2

ODSH improves bacterial clearance in BALF and lung tissues of CF mice. C57BL/6 mice (WT) and CFTR^−/− mice (CF) were intratracheally inoculated with Pseudomonas aeruginosa (PA) at T = 0 and were randomized to receive via i.p. administration of saline or ODSH at 8.3 or 25 mg/kg at T = 0 and 12 h.  A Bronchoalveolar lavage fluid (BALF) and B lung homogenate were harvested 18 h after infection (T = 18 h) and were analyzed for the amount of viable bacteria by plating serial dilutions of BALF samples followed by colony assay. Bacterial load in the samples is expressed as log CFUs/mL in BALF or lungs. Data represent the mean ± SEM of four independent experiments (n = 10–14). One-way ANOVA was used for multiple group comparison to determine statistical significance between control CF group and other groups