Fig. 5
From: Depleting SOX2 improves ischemic stroke via lncRNA PVT1/microRNA-24-3p/STAT3 axis
Restored miR-24-3p abolishes PVT1 overexpression-induced neurological impairment, motor behavioral disorder and pathological damage in MCAO rats. A Neurological defect scores of rats in each group after PVT1 overexpression and miR-24-3p up-regulation (n = 8 rats per group); B Forelimb foot fault placing test scores of rats in each group after PVT1 overexpression and miR-24-3p up-regulation (n = 5 rats per group); C Parallel bar experiment scores of rats in each group after PVT1 overexpression and miR-24-3p up-regulation (n = 5 rats per group); D Rope climbing test scores of rats in each group after PVT1 overexpression and miR-24-3p up-regulation (n = 5 rats per group); E Brain water content of rats in each group after PVT1 overexpression and miR-24-3p up-regulation (n = 8 rats per group); F HE staining of rat brain injury in each group after PVT1 overexpression and miR-24-3p up-regulation (× 200; scale bar = 50 μm, n = 8 rats per group; arrow indicated that the nucleus of neurons appears with pyknosis); ^P < 0.05 compared with the Lenti-NC group; $P < 0.05 compared with the Lenti-PVT1 group