Fig. 2

Microarray analysis of differentially expressed mRNAs between six pancreatic ductal adenocarcinoma (T) samples and paired non-tumor (N) samples. A Hierarchical cluster analysis of differentially expressed (≥ twofold change) mRNAs between six pancreatic ductal adenocarcinoma (T) samples and paired non-tumor (N) samples. The red color indicates upregulation, while the green color indicates downregulation. B A total of 222 mRNAs, with the upregulation of 66 mRNAs and downregulation of 156 mRNAs, were selected for clustering. C Gene ontology analysis of the differentially expressed genes (DE) between six PDAC tumors and paired non-tumor samples. The upregulated mRNAs are mainly aggregated in (a) the “spliceosome,” (b) “metabolic pathway,” and (c) “glycosaminoglycan and keratan sulfate” (framed in red). The downregulated mRNAs mainly associated with (d) “Staphylococcus aureus infection,” (e) “graft-versus-host disease,” and (f) “type I diabetes mellitus” (framed in green)