Fig. 1

LncRNA MAPKAPK5-AS1 is upregulated, while miR-124-3p is down-regulated in myocardial injury induced by LPS. A TUNEL staining for cell apoptosis (gray) in the groups of Vehicle, LPS (5 mg/mg), and LPS (10 mg/kg), scale bar: 50 μm. B IHC for TNF-α positive cells (gray) per × 200 field in groups of vehicle, LPS (5 mg/mg), and LPS (10 mg/kg), scale bar: 50 μm. C IHC for CD68 positive cells (gray) per 200 × field in the groups of Vehicle, LPS (5 mg/mg), and LPS (10 mg/kg). D and E LPS treatment reduced the cardiac function in a dose-dependent manner. F Relative MAPKAPK5-AS1 expression in heart tissue in the groups of Vehicle, LPS (5 mg/mg), and LPS (10 mg/kg). G MiR-124-3p expression in heart tissue in the groups of Vehicle, LPS (5 mg/mg), and LPS (10 mg/kg). Each column represents the mean ± SEM. Statistical differences were evaluated with One-way ANOVA followed by Tukey’s post-hoc test. *P < 0.05, **P < 0.01, ***P < 0.001, n = 5