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Table.1 Different roles of H19 in promoting osteogenic differentiation

From: Role of long non-coding RNA H19 in the development of osteoporosis

Expression of H19 Sampling tissue Mode of action Targets and pathways affected Changes of targets Refs.
Up-regulated Human BMSCs Precursor of miR-675 miR-675/TGF-β1/Smad3/HDAC axis
Promoting Wnt/β-catenin pathway
Up-regulated of miR-675 Huang et al. (2015)
Up-regulated Mouse BMSCs Regulating miRNAs that target Notch ligands and receptors miRNAs/ligands/Notch/BMP9 axis
Promoting Notch pathway
Up-regulated of miRNAs Liao et al. (2017)
Up-regulated Human serum and Mouse BMSCs Binding to FOX2 FOX2
Promoting Wnt/β-catenin pathway
Up-regulated Zhou et al. (2019)
Up-regulated Femurs of rats Targeting DKK4 DKK4
Promoting Wnt/β-catenin pathway
Down-regulated Li et al. (2017)
Down-regulated Human blood and Human BMSCs Mediating miR-19b-3p miR-19b-3p
H19/miR-19b-3p/RUNX2 axis
Up-regulated Xiaoling et al. (2020)
Up-regulated Tibia of mice Binding to P53 P53 Down-regulated Zhou et al. (2018)
Up-regulated Human BMSCs Sponging for miR-138 miR-138/FAK/ERK/Runx2 axis Up-regulated Wu et al. (2018a, b)
Up-regulated Human BMSCs Sponging for miR-141 and miR-22 miR-141 and miR-22
Promoting Wnt/β-catenin pathway
Up-regulated Liang et al. (2016)
Up-regulated Mouse BMSCs Sponging for miR-188 H19/miR-188/LCoR axis Down-regulated Wang et al. (2018)
Up-regulated Human BMSCs Sponging for miR-140-5p H19miR-140-5p/SATB2 axis Down-regulated of miR-140-5p Bi et al. (2020)
Up-regulated Human BMSCs Sponging for miR-214-5p H19/miR-214-5p/BMP2 axis Down-regulated of miR-214-5p He et al. (2021)
  1. BMSCs bone marrow mesenchymal cells, miRNAs microRNAs, HADC Histone deacetylase, BMPs bone morphogenetic proteins, FOXC2 Forkhead box c2, DKK4 Dickkopf protein 4, FAK Focal adhesion kinase, ERK extracellular signal-regulated kinase, LCoR Ligand-dependent corepressor, SATB2 special AT-rich sequence-binding protein 2