Table.1 Different roles of H19 in promoting osteogenic differentiation
From: Role of long non-coding RNA H19 in the development of osteoporosis
Expression of H19 | Sampling tissue | Mode of action | Targets and pathways affected | Changes of targets | Refs. |
|---|---|---|---|---|---|
Up-regulated | Human BMSCs | Precursor of miR-675 | miR-675/TGF-β1/Smad3/HDAC axis Promoting Wnt/β-catenin pathway | Up-regulated of miR-675 | Huang et al. (2015) |
Up-regulated | Mouse BMSCs | Regulating miRNAs that target Notch ligands and receptors | miRNAs/ligands/Notch/BMP9 axis Promoting Notch pathway | Up-regulated of miRNAs | Liao et al. (2017) |
Up-regulated | Human serum and Mouse BMSCs | Binding to FOX2 | FOX2 Promoting Wnt/β-catenin pathway | Up-regulated | Zhou et al. (2019) |
Up-regulated | Femurs of rats | Targeting DKK4 | DKK4 Promoting Wnt/β-catenin pathway | Down-regulated | Li et al. (2017) |
Down-regulated | Human blood and Human BMSCs | Mediating miR-19b-3p | miR-19b-3p H19/miR-19b-3p/RUNX2 axis | Up-regulated | Xiaoling et al. (2020) |
Up-regulated | Tibia of mice | Binding to P53 | P53 | Down-regulated | Zhou et al. (2018) |
Up-regulated | Human BMSCs | Sponging for miR-138 | miR-138/FAK/ERK/Runx2 axis | Up-regulated | |
Up-regulated | Human BMSCs | Sponging for miR-141 and miR-22 | miR-141 and miR-22 Promoting Wnt/β-catenin pathway | Up-regulated | Liang et al. (2016) |
Up-regulated | Mouse BMSCs | Sponging for miR-188 | H19/miR-188/LCoR axis | Down-regulated | Wang et al. (2018) |
Up-regulated | Human BMSCs | Sponging for miR-140-5p | H19miR-140-5p/SATB2 axis | Down-regulated of miR-140-5p | Bi et al. (2020) |
Up-regulated | Human BMSCs | Sponging for miR-214-5p | H19/miR-214-5p/BMP2 axis | Down-regulated of miR-214-5p | He et al. (2021) |